Poison has updated Hostcore to work on the latest Custom Firmware:

I did not know there was 5.00 until Albert Markish send me an email telling me that I should update Hostcore to support 5.00 CFW. Actually I had not touched PSP for more than 3 months, but I should apologize to who wait for this release, huh. and there would be an update of CXMB these days. BTW, my current major work is about Human MicroRNA computational prediction methods(mainly using Drasha/Dicer site), the PSP group is very huge, right? if somebody like to share some information with me about that, email me, thanks.

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