Something like Maple Story might work rather well on two fronts:
1. This game could be put onto both the DS and the Wii - players could use the same username/characters so they can "game on the go" and then, when they get home, continue the game on the "big screen"
2. There's already the headset for the Nintendo DS - something that could easily be tied into the Wii version (say via a bluetooth headset). The game could then use this voice chat feature with "friends" (so you don't have some unknown butthead screaming obscenities in your ear).
I'd be curious to see one like this. I'm not into the MMO scene, but if done right it could be rather popular.
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