Confirmed: no run-and-gun in Resident Evil 5. Ever.

Isn't it just like the internet to propagate unsubstantiated rumors. The latest such rumor surrounding the upcoming survival horror shooter Resident Evil 5 may have given the game some free publicity, but Capcom has decided that enough is enough. It's squashing the rumor once and for all in its latest community blog post. The "action" controls will not allow you to move and shoot simultaneously. Chris Redfield's testosterone-filled body makes multitasking an impossibility.

"While RE5 is very action-heavy, the base RE game design mechanic of holding fast while shooting remains," says the Capcom blog. Newcomers to the series may need to make some "mental readjustments," but the controls have remained this way to establish a sense of risk and danger while in combat. The new controls will instead grant "more natural motion to the second analog stick on your 360 or PS3 controller," allowing you to strafe. We're sure there are strong advocates for both sides of the argument amongst Resident Evil 5's audience. Maybe not Chris Redfield strong ... but strong.

http://www.joystiq.com/2009/02/02/co...t-evil-5-ever/

At first when I saw the strafe option, I assumed you could POSSIBLY shoot and walk, but realized in one second you couldn't after seeing that strafe only worked when you stood there XD
To also add, I dunno if RE5 would work with that ability or not, a lot of the suspense is in the fact you have to stop and aim, cause you feel in a sense helpless, as if something is going to come up behind you and kill you.