Every now and again, when I go to open my map (ms0:/PSP/GAME/MAPVI/maps/_HomeNEW, for the record), MapThis! freezes. I may have tracked down the problem though, "map_pref.txt" seems to get corrupt (for some reason, maybe a plugin or something).
Changing the file permission to "read-only" helps, and if that fails, just delete the file with FileAssistant or whatever. This is all just FYI, it helped me.