Well Assassin's Creed has locked up on my 3 times since I got it (once when my friend was playing). Nothing major, but kinda annoying.
COD4 has been bricking PS3s from what I have seen from the official PS boards, but COD3 takes the cake on that one. Whether or not COD4 is due to 2.0 or because Activision sucks nuts, I don't know.