Probably something to do with 1.50 based homebrew not liking the large size of the card and writing incorrectly to it and corrupting things.
The 1.5 kernal can not address memory sticks larger than 4GB.
I am unsure if there is any way around this, I thought the issues with larger memory sticks were fixed in newer custom FW but perhaps not for 1.5 based things.
One of those unofficial gpSP versions may be in kernel 3.x format and so may not have the same issue (I really don't know, I have never used the unofficial ones and I have a 4GB card). Perhaps worth a try.
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