For me it depends entirely on the game. I have, over the years, been less and less involved with MP gaming. That said I wont buy a MP game and never experience the MP!
I find that with games that have no MP, ie BioShock, DeadSpace, Mass Effect,etc. The storyline is usually top notch and the overall gameplay is just as good (less glitches). Some multiplayer games focus on the MP to much and the SP suffers as a result *cough*Battlefield: Bad Company *cough*
Peace
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