Cannabis Guide app

[NoQuarter]

The active ingredient of marijuana could be considerably better at suppressing the abnormal clumping of malformed proteins that is a hallmark of Alzheimer's disease than any currently approved prescription drugs.

Scientists report the finding in the Oct. 2 issue of the journal Molecular Pharmaceutics.

About 4.5 million Americans suffer from Alzheimer's disease, which gradually destroys memory. As more people survive into old age, cases of Alzheimer’s disease are expected to triple over the next 50 years. There is no known cure.

• Click here to visit FOXNews.com's Human Body Center.

The researchers looked at THC, the compound inside marijuana responsible for its action on the brain.

Computer models suggested THC might inhibit an enzyme with the tongue-twisting name of acetylcholinesterase (also called AChE) that is linked to Alzheimer's.

(Story continues below)

[dagger89]

Marijuana's damage to short-term memory seems to occur because THC alters the way in which information is processed by the hippocampus, a brain area responsible for memory formation. In one study, researchers compared marijuana smoking and nonsmoking 12th-graders' scores on standardized tests of verbal and mathematical skills. Although all of the students had scored equally well in 4th grade, those who were heavy marijuana smokers, i.e., those who used marijuana seven or more times per week, scored significantly lower in 12th grade than nonsmokers. Another study of 129 college students found that among heavy users of marijuana critical skills related to attention, memory, and learning were significantly impaired, even after they had not used the drug for at least 24 hours.13


Would you look at that, memory problems... hmm, that would relate to dead brain cells. Too many dead brain cells= mental retardation or death.

http://www.ncbi.nlm.nih.gov/entrez/q...=pubmed_docsum
Hmmm, disease, how nice

[ACID]

Im assuming all you guys would have loevd to have gone with me to jamaica last year.

[opiate81]

sweet app man!!!! very handy
oh and btw I dont see stoned people brawling down the street on the weekend or beating the crap outta their wives.. its the people taking the legal drug alcohol.. stoners just wanna get high, eat, play games and watch movies!
it was the only thing that kept me sane when designing websites

who cares anyways its legal to grow one plant for personal use here in sth australia
so thanks again for the sweet app gunntims0103

\m/

[NoQuarter]

READ


Cannabidiol and (-)Delta 9-tetrahydrocannabinol are neuroprotective antioxidants
A. J. Hampson*,dagger , M. GrimaldiDagger , J. Axelrod*, and D. Wink§

* Laboratory of Cellular and Molecular Regulation, National Institutes of Mental Health, Bethesda, MD 20892; Dagger Laboratory of Adaptive Systems, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892; and § Radiology and Biology Branch, National Cancer Institute, Bethesda, MD 20892

Contributed by Julius Axelrod, April 27, 1998

The neuroprotective actions of cannabidiol and other cannabinoids were examined in rat cortical neuron cultures exposed to toxic levels of the excitatory neurotransmitter glutamate. Glutamate toxicity was reduced by both cannabidiol, a nonpsychoactive constituent of marijuana, and the psychotropic cannabinoid (-)Delta 9-tetrahydrocannabinol (THC). Cannabinoids protected equally well against neurotoxicity mediated by N-methyl-D-aspartate receptors, 2-amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)propionic acid receptors, or kainate receptors. N-methyl-D-aspartate receptor-induced toxicity has been shown to be calcium dependent; this study demonstrates that 2-amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)propionic acid/kainate receptor-type neurotoxicity is also calcium-dependent, partly mediated by voltage sensitive calcium channels. The neuroprotection observed with cannabidiol and THC was unaffected by cannabinoid receptor antagonist, indicating it to be cannabinoid receptor independent. Previous studies have shown that glutamate toxicity may be prevented by antioxidants. Cannabidiol, THC and several synthetic cannabinoids all were demonstrated to be antioxidants by cyclic voltametry. Cannabidiol and THC also were shown to prevent hydroperoxide-induced oxidative damage as well as or better than other antioxidants in a chemical (Fenton reaction) system and neuronal cultures. Cannabidiol was more protective against glutamate neurotoxicity than either ascorbate or alpha -tocopherol, indicating it to be a potent antioxidant. These data also suggest that the naturally occurring, nonpsychotropic cannabinoid, cannabidiol, may be a potentially useful therapeutic agent for the treatment of oxidative neurological disorders such as cerebral ischemia.

Cannibis does not cause brain damage!

[kando]

its technically legal up to 1 ounce in denver, colorado.....

http://www.cannabisculture.com/articles/4570.html

Denver voters make adult possession of one ounce or less of marijuana legal.

Denver became the first city in the nation to make the private use of marijuana legal for adults 21 and older as an alternative to alcohol, a far more harmful drug. By 10.45 p.m. Tuesday night, with 100% of the votes tallied, the Alcohol-Marijuana Equalization Initiative had passed 53.49% YES to 46.51% NO....


...The campaign pointed to government reports and scholarly studies that show alcohol is a contributing factor in domestic violence, sexual assaults, and other violent crimes, as well as overdose deaths, whereas the use of marijuana has never been linked to such violent behavior and there has never been a marijuana overdose death in history.

go democracy!!

[Kramer]

sweet app man!!!! very handy
oh and btw I dont see stoned people brawling down the street on the weekend or beating the crap outta their wives.. its the people taking the legal drug alcohol.. stoners just wanna get high, eat, play games and watch movies!
it was the only thing that kept me sane when designing websites

who cares anyways its legal to grow one plant for personal use here in sth australia
so thanks again for the sweet app gunntims0103

\m/

In W.A we can have three bushies under a metre high I think.

[BL4Z3D247]

Im assuming all you guys would have loevd to have gone with me to jamaica last year.

uhhh YEH!!!!! lol , Jamaican's rock, the ones i have met here in the US are awesome...like Foyd he was awesome, we used to smoke blunts all day(installing directv satellite systems) and we'd go get beef patties when we had the munchies...ah those were the days

[dagger89]

READ


Cannabidiol and (-)Delta 9-tetrahydrocannabinol are neuroprotective antioxidants
A. J. Hampson*,dagger , M. GrimaldiDagger , J. Axelrod*, and D. Wink§

* Laboratory of Cellular and Molecular Regulation, National Institutes of Mental Health, Bethesda, MD 20892; Dagger Laboratory of Adaptive Systems, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892; and § Radiology and Biology Branch, National Cancer Institute, Bethesda, MD 20892

Contributed by Julius Axelrod, April 27, 1998

The neuroprotective actions of cannabidiol and other cannabinoids were examined in rat cortical neuron cultures exposed to toxic levels of the excitatory neurotransmitter glutamate. Glutamate toxicity was reduced by both cannabidiol, a nonpsychoactive constituent of marijuana, and the psychotropic cannabinoid (-)Delta 9-tetrahydrocannabinol (THC). Cannabinoids protected equally well against neurotoxicity mediated by N-methyl-D-aspartate receptors, 2-amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)propionic acid receptors, or kainate receptors. N-methyl-D-aspartate receptor-induced toxicity has been shown to be calcium dependent; this study demonstrates that 2-amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)propionic acid/kainate receptor-type neurotoxicity is also calcium-dependent, partly mediated by voltage sensitive calcium channels. The neuroprotection observed with cannabidiol and THC was unaffected by cannabinoid receptor antagonist, indicating it to be cannabinoid receptor independent. Previous studies have shown that glutamate toxicity may be prevented by antioxidants. Cannabidiol, THC and several synthetic cannabinoids all were demonstrated to be antioxidants by cyclic voltametry. Cannabidiol and THC also were shown to prevent hydroperoxide-induced oxidative damage as well as or better than other antioxidants in a chemical (Fenton reaction) system and neuronal cultures. Cannabidiol was more protective against glutamate neurotoxicity than either ascorbate or alpha -tocopherol, indicating it to be a potent antioxidant. These data also suggest that the naturally occurring, nonpsychotropic cannabinoid, cannabidiol, may be a potentially useful therapeutic agent for the treatment of oxidative neurological disorders such as cerebral ischemia.

Cannibis does not cause brain damage!

Tell me, do you even understand what that is saying? Because last time I checked, we weren't rats.

And guess what, just cuz sumthing my be good in one case, in others it can be bad.... Sickle cell anemia is one example of where it can be benefital to be heterozygous for sickle cell in conditions where malayria is present. But it can also be deadly.

Just because sumthing is good in one case doesn't mean its good in ALL cases

[NoQuarter]

Actually yes I do
You know nothing about me.I know you go to medical school where so much of your knowledge has come from studies such as these.

There's a ton more where this came from