I have not used any of the slot 1 cards. For me I would get one that uses microSD, just because you can upgrade the amount of space. I own a M3 SD with Passcard and I think it works very well. That's why I personally would get a M3 Simply, because M3 has been reliable for me.
When you say 4 gb for the DS-Xtreme, that's 4 gigabits, which is 512 megabytes. It's confusing.
But I'd wait to see what some DS experts say.
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