?? Wait, you're looking into purchasing one of these retro consoles?
The Duo has no CD region restrictions (at least the American version doesn't, come to think of it, I don't deffinitively know about the -R). It's the HuCards that you have to get matched to the system, but there aren't that many great HuCard games anyway. In any case, nearly all of the games that were released in America were released in Japan first, and some of the greatest (Dracula X, Ys IV, etc...) never made it to America, so I wouldn't worry about any possible region restrictions.
These days, the Duo is going to be a "true" retro experience -- 8bit graphics and somewhat quirky games (Strip Fighter II ?!?!!), but at least the loading times are bearable. The CDZ is much more contemporary in terms of library and graphics, but I'm sure you're aware that it's got painful loading times.
Personally, I'd go with the Duo. Virtually all of my best gaming memories are on that system. Almost all of the games available for the CDZ are fighters which are available on more current systems, and most of the games that aren't fighters are pretty much coin-munching arcade games (which, while fun for a while provide little *real* challenge), so I personally don't see much point in getting it. I know you said the games aren't much of a deciding factor, but for my money, the Duo library tends to have a higher replay value.
Just my thoughts. My appologies if I'm missing something...
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