MGS4 wont, because Kojima has stated time and again that he wants a 50gb, SINGLE LAYER BluRay disc for MGS4. And to quote him:
"Its not so much about the graphics, but the sounds. We can do some amazing things with sounds."
Point is, he aint taking any shortcuts with this game and a DVD just isn't feasible for a game that the director of is aiming at filling 50gb. Knowing Kojima, he'll get it close.
Resistance is also 16gb which is more than twice that of a DVD. Assuming that that used space isn't dummy data or padding and is actual data, then its fairly safe to say that BDs are necessary.
And as 808 said:
"There really is no point of having a next-gen machine with a last-gen storage medium."
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