Yes, there are different size motherboards but most conform to the ATX standard. Check the Wiki page here under the variants section. When buying case and mobo, check descriptions carefully to ensure they'll accept each other. i.e, a case supporting Standard ATX will take Standard ATX and Micro ATX. A case of Micro ATX dimentions will take Micro ATX but not Standard ATX as it's too big to fit. Hope this helps some.
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