slot-2 devices support DS binaries and GBA binaries. A .ds.gba file is actually a DS binary that's made to run off a GBA flash cart. A regular .gba file is a GBA binary, and only slot-2 cards will run them.
The MK5 is a slot-1 device and as such it won't run any GBA binaries. That slot-2 part is only used for flashing the memory within the slot-1 card.
If you want a true slot-2 device, the Supercard (not Rumble) or M3 (not Pro) is recommended. If you want a combo deal (sort of like what you thought the MK5 was) you can get a slot-1 device like the M3 Simply combined with the slot-2 EZ-V "3 in 1" expansion pack, which will give you GBA playback and extra RAM for use with homebrew that uses it.
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