first of all, the emulation is not perfect, so some games won't run at full speed or even at a playable speed at all, regardless what you do (doom for example).
all you can do is: turn on cpu optimizations and turn off sound. turning off transparency can give a major speed boost (if the game heavily relies on that) but renders some games unplayable. you have to test that.
get european roms. read the sticky in this forum to know why
if you have a sound option in the game then set it to mono (even if your emulator already runs in mono mode). that seems to take some impact from the emulator. running a game in mono generally already speeds things up by the way
the number of roms on a disk doesn't affect performance.
i'm gonna test the games you mentioned to see how playable i can get them
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